From Clinical Guideline to Order Set to Patient Harm: JAMA published a case and editorial regarding the well-intentioned but flawed application of clinical guidelines to order sets and the perverse incentives that can lead to patient harm. Here is the reference: JAMA. 2018;319(12):1207-1208. doi:10.1001/jama.2018.1666 In this particular case a patient was treated for an MI with a coronary artery stent and developed a complete heart block after the procedure. Medications that were not indicated to treat this complication were in the order set and the physician, when interviewed about his choice of medications, chose a beta-blocker (contraindicated based on robust data of use after a STEMI) that lead to worsening of the patient. He stated that he chose this medication as per the alert in the CDS that this was a "quality metric". I think it is interesting that providers are swayed against their better judgement to choose a medication from a set of orders that was incomp...